Browsing by Author "Santos, José Luis"
Now showing items 1-20 of 29
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Valenzuela Yuraidini, Carlos; Santos, José Luis (1996)A model for random molecular evolution based on recurrent mutation is proposed. Recurrent mutation replaces completely any original base in a nucleotidic site. This occurs if more than four times the number of reproductive ...
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Arroyo, Patricia; Lera Marques, Lydia; Sánchez, Hugo; Bunout Barnett, Daniel; Santos, José Luis; Albala Brevis, Cecilia (2007)Background: Functional limitations limit the independence and jeopardize the quality of life of elderly subjects. Aim: To assess the association between anthropometric measures and body composition with functional limitations ...
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Valladares Vega, Macarena; Obregón, Ana María; Weisstaub, Gerardo; Burrows, Raquel; Patiño, Ana; Ho-Urriola, Judith; Santos, José Luis (Grupo Aula Médica, 2015)Introducción: La leptina (LEP) se produce principalmente en el tejido adiposo y actúa en el hipotálamo regulando la ingesta energética. Mutaciones en el gen LEP o en su receptor (LEPR) que generen obesidad monogénica son ...
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Valladares, Macarena; Obregón, Ana María; Weisstaub Nuta, Sergio; Burrows, Raquel; Patiño, Ana; Ho Urriola, Judith; Santos, José Luis (SENPE, 2015)Introducción: La leptina (LEP) se produce principalmente en el tejido adiposo y actúa en el hipotálamo regulando la ingesta energética. Mutaciones en el gen LEP o en su receptor (LEPR) que generen obesidad monogénica son ...
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Mimbacas, Adriana; Pérez Bravo, Fernando; Santos, José Luis; Pisciottano, Carmen; Grignola, Rosario; Javiel, Gerardo; Jorge, Ana María; Cardoso, Horacio (KLUWER ACADEMIC PUBL, 2004-10)Susceptibility to the type 1 diabetes is genetically controlled and there is an increased risk associated with the presence of some specific alleles of the human leukocyte antigens class II loci (DQA1 and DQB1 genes). The ...
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Ochoa, María C.; Santos, José Luis; Azcona, Cristina; Moreno Aliaga, María J.; Martínez González, Miguel A.; Martínez, J. Alfredo; Marti, Amelia (2007)A number of studies have yielded controversial results on the association between polymorphisms in UCP2 and UCP3 genes with obesity and its comorbidities. The discrepancy among studies might be partially explained by the ...
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Ochoa, María C.; Santos, José Luis; Azcona, Cristina; Moreno Aliaga, María J.; Martínez González, Miguel A.; Martínez, J. Alfredo; Marti, Amelia (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2007-12)A number of studies have yielded controversial results on the association between polymorphisms in UCP2 and UCP3 genes with obesity and its comorbidities. The discrepancy among studies might be partially explained by the ...
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Yáñez López, José; González, Ruth; Angulo, Jenniffer; Vidal, Rodrigo; Santos, José Luis; Martínez, Víctor (BLACKWELL PUBLISHING, 2008-11)The emu (Dromaius novaehollandiae), a member of ratite family, is native to Australia and has been introduced to other countries worldwide. In this work, 10 polymorphic microsatellite loci were isolated and characterized ...
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Pardo Vargas, Rosa; Suazo, José; Castillo Taucher, Silvia; Vargas, Marcela; Zalavaria, Andrea; Santos, José Luis; Blanco Castillo, Rafael; Rotter, Karin; Solar, Margarita; Tapia, Eva (Universidad de Chile, 2014)Background: Mandatory fortification with folic acid (FA) was implemented in Chile in 2000. Thereafter, the rate of spina bifida decreased by 52 to 55%. Genetic abnormalities in folate metabolism may be involved in the ...
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Albala Brevis, Cecilia; Villarroel, Ana; Santos, José Luis; Ángel Badillo, Bárbara; Lera Marques, Lydia; Liberman Guendelman, Claudio; Sánchez, Hugo; Pérez Bravo, Francisco (Diabetes Research and Clinical Practice, 2007-08)Objective: The FABP2 Ala54Thr polymorphism has been associated with insulin resistance and diabetes in several populations. The aim of this study was to estimate the prevalence of FABP2 genotypes in 223 Chilean subjects ...
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Suazo, José; Pardo Vargas, Rosa; Castillo, Silvia; Martin, Luz Maria; Rojas, Francisca; Santos, José Luis; Rotter, Karin; Solar, Margarita; Tapia, Eva (SAGE, 2013)Obese/diabetic mothers present a higher risk to develop offspring with myelomeningocele (MM), evidence supporting the role of energy homeostasis-related genes in neural tube defects. Using polymerase chain reaction–restriction ...
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Arrese, Marco; Arab, Juan P.; Riquelme, Arnoldo; Benítez, Carlos E.; Barrera, Francisco; Soza, Alejandro; Miquel, Juan F.; Hernández Rocha, Cristian; Suazo, José; Duarte, Ignacio; Robles, Camila; Sandoval, Daniela; Santos, José Luis (Wiley & Sons, 2015)
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Pérez Bravo, Francisco; Santos, José Luis; Calvillán C, Marcelo; Carrasco, Elena P. (1998)Background: Inherited susceptibility to type 1 diabetes is partially determined by HLA genes. HLA-DQA1 and DQB1 alleles have been chosen as the most sensitive susceptibility markers. Family studies are a good method to ...
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Arroyo Albala, Patricia; Lera Marques, Lydia; Sánchez, Hugo; Bunout Barnett, Daniel; Santos, José Luis; Albala Brevis, Cecilia (Sociedad Médica de Santiago, 2007-07)Functional limitations limit the independence and jeopardize the quality of life of elderly subjects. Aim: To assess the association between anthropometric measures and body composition with functional limitations in ...
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Sir Petermann, Lidia; Ángel Badillo, Bárbara; Maliqueo Yevilao, Manuel; Santos, José Luis; Riesco, María Virginia; Toloza, Henry; Pérez Bravo, Francisco (ELSEVIER, 2004-10)OBJECTIVE: We evaluated metabolic parameters in Chilean women with polycystic ovary syndrome (PCOS) who were carriers and non-carriers of the glycine-to-arginine substitution at codon 972 (Gly972Arg) variant of insulin ...
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Albala Brevis, Cecilia; Santos, José Luis; Cifuentes, Mariana; Villarroel, Ana C.; Lera Marques, Lydia; Liberman Guendelman, Claudio; Ángel Badillo, Bárbara; Pérez Bravo, Francisco (NORTH AMER ASSOC STUDY OBESITY, 2004-02)Objective: To assess the association between the Ala54Thr genetic polymorphism of the fatty acid-binding protein 2 (FABP2) gene with insulin resistance and obesity. Research Methods and Procedures: According to a sampling ...
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Suazo, José; Santos, José Luis; Jara Sosa, Lilian; Blanco Castillo, Rafael (WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-10-15)
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Ho Urriola, Judith; Guzmán Guzmán, Iris P; Smalley, Susan V.; González, Andrea; Weisstaub Nuta, Sergio; Domínguez Vásquez, Patricia; Valladares, Macarena; Amador, Paola; Hodgson, María Isabel; Obregón, Ana M.; Santos, José Luis (Elsevier, 2014)Objective: The aim of this study was to assess the association between melanocortin-4 receptor (MC4R) rs17782313 alleles with obesity and eating behavior scores in Chilean children. Methods: A case–control study was ...
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Pérez Bravo, Francisco; Oyarzún, Amaya; Carrasco Piña, Elena; Ángel Badillo, Bárbara; Albala Brevis, Cecilia; Santos, José Luis (SOC MEDICA SANTIAGO, 2004-04)Background: Type 1 diabetes is an organ specific autoimmune disease whose incidence is increasing worldwide. A functional imbalance in cytokine production resulting in dominance of T helper (Th1) over Th2-type response has ...
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Santos, José Luis; Pérez Bravo, Francisco; Martínez, J. A.; Montalvo, Domingo; Albala Brevis, Cecilia; Carrasco, Elena (Elsevier Science Inc., 2002)OBJECTIVE: We assessed the association between Gln27Glu and Trp64Arg genetic polymorphisms of the 2 (ADRB2) and 3 (ADRB3) adrenergic receptor genes with body mass index and other cardiovascular risk factors. METHODS: ...